An image matrix corresponding to the region specified by Source Image Region shall be returned with its size corresponding to the specified normalized coordinate values.

If the Presentation UID parameter is present, the region shall be selected after the corresponding presentation state has been applied on the images.

the Query Parameter specifies an ill-defined region,

there are greater or fewer than four parameter values present, or

any of the parameters do not conform to the requirements specified in Section 9.5.1.2.5