CP-1448 Add blood normalized IAUC codes <informaltable rules="all" frame="box"> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Status</para> </td> <td rowspan="1" colspan="1" valign="top"> <para>Submitted</para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Date of Last Update</para> </td> <td rowspan="1" colspan="1" valign="top"> <para>2015/01/14</para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Person Assigned</para> </td> <td rowspan="1" colspan="1" valign="top"> <para>David Clunie</para> <para><link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="mailto:dclunie@dclunie.com"/></para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Submitter Name</para> </td> <td rowspan="1" colspan="1" valign="top"> <para>David Clunie</para> <para><link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="mailto:dclunie@dclunie.com"/></para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Submission Date</para> </td> <td rowspan="1" colspan="1" valign="top"> <para>2014/12/04</para> </td> </tr> </informaltable> <informaltable rules="all" frame="box"> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Correction Number CP-1448</para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Log Summary: Add blood normalized IAUC codes</para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"> <para>Name of Standard</para> <para>PS3.16 2015a</para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top"><para>Rationale for Correction:</para> <para>In Dynamic Contrast MR, the initial area under the (Gd) concentration curve may be reported with or without blood normalization using an arterial input function. The QIBA DCE-MRI profile uses the blood normalized variant in its claim.</para> <para>Pre-coordinated codes are added to distinguish the two. Also, a 180 second interval is added, since this is sometimes used instead of 60 or 90 seconds (see the QIBA DCE-MRI profile reproducibility data literature summary). Pre-coordinated codes specific to the type of contrast agent (e.g., IAUGC90BN in addition to IAUC90BN) are not thought to be necessary.</para> </td> </tr> <tr> <td rowspan="1" colspan="1" valign="top">Correction Wording:</td> </tr> </informaltable> </chapter> <chapter> <title/> <section> <title/> <informaltable rules="all" frame="box"> <tr> <td> <para><emphasis role="italic">Amend DICOM PS3.16 as follows (changes to existing text are bold and <emphasis role="bold"><emphasis role="underline" >underlined</emphasis></emphasis> for additions and <emphasis role="bold" ><emphasis role="strikethrough">struckthrough</emphasis></emphasis> for removals):</emphasis></para> </td> </tr> </informaltable> </section> <section label="CID 4109" status="3" xml:id="sect_CID_4109"> <title>Model-Independent Dynamic Contrast Analysis Parameters Type: Extensible Version: 20141110yyyymmdd
Model-Independent Dynamic Contrast Analysis Parameters
Coding Scheme Designator Code Value Code Meaning
DCM 126320 IAUC
DCM 126321 IAUC60
DCM 126322 IAUC90
DCM ddddd1 IAUC180
DCM ddddd2 IAUCBN
DCM ddddd3 IAUC60BN
DCM ddddd4 IAUC90BN
DCM ddddd5 IAUC180BN
DCM 126370 Time of Peak Concentration
... ... ...
(ddddd4, DCM, "IAUC90BN") can be used for DCE-MRI using a Gd-based contrast agent to represent the IAUGCBN measurement in the claim of the QIBA DCE MRI Quantification Profile, though the concept itself is not specific to the modality or the contast agent used. See . See also Ng, CS., et al. "Reproducibility of Perfusion Parameters in Dynamic Contrast-Enhanced MRI of Lung and Liver Tumors: Effect on Estimates of Patient Sample Size in Clinical Trials and on Individual Patient Responses." AJR 194, no. 2 (February 1, 2010): W134–40. . The type of contrast agent and the AIF used for blood normalization may or may not be post-cordinated. E.g., voxel-wise IAUGCBN measurements encoded as a parametric map with the quantity defined by the Quantity Definition Sequence (0040,9220) in a Real World Value Map might be described as: (G-C1C6, SRT, "Quantity") = (ddddd4, DCM, "IAUC90BN") (G-C036, SRT, "Measurement Method") = (126362, DCM, "User-defined AIF ROI") (123011, DCM, "Contrast Bolus/Agent") = (C-17800, SRT, "Gadolinium") E.g., a IAUGCBN measurement for an ROI encoded in a structured report might be described as: NUM (ddddd4, DCM, "IAUC90BN") = 0.230 (units are unity, being a normalized value) (G-C036, SRT, "Measurement Method") = (126364, DCM, "Blind Estimation of AIF") Note that the generic ROI measurement templates do not have the contrast bolus/agent as a parameter; this may be implicit from context, or inherited from the (121058, DCM,"Procedure reported") in the parent template.
<informaltable rules="all" frame="box"> <tr> <td> <para><emphasis role="italic">Amend DICOM PS3.16 as follows (changes to existing text are bold and <emphasis role="bold"><emphasis role="underline" >underlined</emphasis></emphasis> for additions and <emphasis role="bold" ><emphasis role="strikethrough">struckthrough</emphasis></emphasis> for removals):</emphasis></para> </td> </tr> </informaltable> </section> <section> <title/> <table rules="all" frame="box" label="D-1" xml:id="table_D-1"> <caption>DICOM Controlled Terminology Definitions</caption> <thead> <tr valign="top"> <th align="center" colspan="1" rowspan="1"> <para> <emphasis role="bold">Code Value</emphasis> </para> </th> <th align="center" colspan="1" rowspan="1"> <para> <emphasis role="bold">Code Meaning</emphasis> </para> </th> <th align="center" colspan="1" rowspan="1"> <para> <emphasis role="bold">Definition</emphasis> </para> </th> <th align="center" colspan="1" rowspan="1"> <para> <emphasis role="bold">Notes</emphasis> </para> </th> </tr> </thead> <tbody> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_126314">126314</para> </td> <td align="left" colspan="1" rowspan="1"> <para>ve</para> </td> <td align="left" colspan="1" rowspan="1"> <para>v<subscript>e</subscript>, the fractional (not absolute) volume of extravascular extracellular space (EES) per unit volume of tissue</para> <para>See Tofts et al, "Estimating Kinetic Parameters From Dynamic Contrast-Enhanced T1-Weighted MRI of a Diffusable Tracer: Standardized Quantities and Symbols", Journal of Magnetic Resonance Imaging, vol. 10, pp. 223–232, 1999.</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_126320">126320</para> </td> <td align="left" colspan="1" rowspan="1"> <para>IAUC</para> </td> <td align="left" colspan="1" rowspan="1"> <para>The intial area under the contrast agent concentration–time curve</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_126321">126321</para> </td> <td align="left" colspan="1" rowspan="1"> <para>IAUC60</para> </td> <td align="left" colspan="1" rowspan="1"> <para>The intial area under the contrast agent concentration–time curve at 60 seconds after the onset time</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_126322">126322</para> </td> <td align="left" colspan="1" rowspan="1"> <para>IAUC90</para> </td> <td align="left" colspan="1" rowspan="1"> <para>The intial area under the contrast agent concentration–time curve at 90 seconds after the onset time</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_ddddd1"><emphasis role="bold"><emphasis role="underline">ddddd1</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">IAUC180</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">The intial area under the contrast agent concentration–time curve at 180 seconds after the onset time</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline"></emphasis></emphasis></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_ddddd2"><emphasis role="bold"><emphasis role="underline">ddddd2</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">IAUCBN</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">The intial area under the contrast agent concentration–time curve, normalized with the corresponding arterial input function, such that IAUC<subscript>BN</subscript> = IAUC / IAUC<subscript>AIF</subscript>.</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline"></emphasis></emphasis></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_ddddd3"><emphasis role="bold"><emphasis role="underline">ddddd3</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">IAUCBN60</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">The intial area under the contrast agent concentration–time curve at 60 seconds after the onset time, normalized with the corresponding arterial input function, such that IAUC60<subscript>BN</subscript> = IAUC60 / IAUC60<subscript>AIF</subscript>.</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline"></emphasis></emphasis></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_ddddd4"><emphasis role="bold"><emphasis role="underline">ddddd4</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">IAUCBN90</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">The intial area under the contrast agent concentration–time curve at 90 seconds after the onset time, normalized with the corresponding arterial input function, such that IAUC90<subscript>BN</subscript> = IAUC90 / IAUC90<subscript>AIF</subscript>.</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline"></emphasis></emphasis></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_ddddd5"><emphasis role="bold"><emphasis role="underline">ddddd5</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">IAUCBN180</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline">The intial area under the contrast agent concentration–time curve at 180 seconds after the onset time, normalized with the corresponding arterial input function, such that IAUC180<subscript>BN</subscript> = IAUC180 / IAUC180<subscript>AIF</subscript>.</emphasis></emphasis></para> </td> <td align="left" colspan="1" rowspan="1"> <para><emphasis role="bold"><emphasis role="underline"></emphasis></emphasis></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_126330">126330</para> </td> <td align="left" colspan="1" rowspan="1"> <para>tau_m</para> </td> <td align="left" colspan="1" rowspan="1"> <para>τ<subscript>m</subscript>. The mean intracellular water lifetime (τ<subscript>i</subscript>). Used in the Shutter-Speed Model (SSM) of tracer kinetics.</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para>...</para> </td> <td align="left" colspan="1" rowspan="1"> <para>...</para> </td> <td align="left" colspan="1" rowspan="1"> <para>...</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> <tr valign="top"> <td align="center" colspan="1" rowspan="1"> <para xml:id="DCM_126370">126370</para> </td> <td align="left" colspan="1" rowspan="1"> <para>Time of Peak Concentration</para> </td> <td align="left" colspan="1" rowspan="1"> <para>The time at which the concentration-time curve achieves its peak for the first time. Used as a concept name for a value or as a method. E.g., used as a method of calculation for BAT. See Shpilfoygel Med Phys 2008. doi: 10.1118/1.1288669</para> </td> <td align="left" colspan="1" rowspan="1"> <para></para> </td> </tr> </tbody> </table> </section> </chapter> </book>